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Because of the lyonization, inactivation, and formation of Barr bodies in all female cells, only one X chromosome is active at any time.

Thus, triple X syndrome most often has only mild effects or has no effects.

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In Denmark, between 19, 76% of the prenatally diagnosed fetuses with triple-X were aborted. With improved information, the number of abortions diminished.

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The first published report of a woman with a 47, XXX karyotype was by Patricia A. at Western General Hospital in Edinburgh, Scotland, in 1959.

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